Viagra vs sildenafil: What’s the difference between the...
Reviewed by Dr. Anup Jethwa
Short answer
See a doctor about erectile dysfunction (ED) if it happens more than occasionally over a few weeks, even if you otherwise feel completely well.
ED is often one of the earliest warning signs of an underlying health issue, including heart and blood vessel problems, so getting it checked is about more than your sex life.
A few situations need same-day attention: An erection lasting more than four hours, sudden ED alongside chest pain or breathlessness, or ED with pain, a lump, or curvature.
Most men put this off.
ED is a common story: A few frustrating weeks, then months, then a couple of years of quietly hoping it sorts itself out.
If that sounds familiar, you're not being dramatic and you're not alone.
This guide won't tell you that ED is "all in your head," or that it will simply pass.
Sometimes it does pass on its own.
Often, though, it's your body flagging something worth investigating, and the earlier that happens, the better the outcome tends to be.
This guide lays out all you need to know about the causes of ED, signs and symptoms of identifying ED, and when you should see a doctor for it.
Before you begin: A little bit about OnlineClinic
OnlineClinic has been operating since 2011 and has treated more than 2.1 million patients.
The pharmacy is registered with the General Pharmaceutical Council (GPhC), our prescribers are registered with the General Medical Council (GMC), and the service is regulated by the Care Quality Commission (CQC).
As of September 2026, on Trustpilot, the service rating is 4.6 out of 5 based on 6,837 reviews.
More common than most men expect.
In the Massachusetts Male Aging Study, just over half of men aged 40 to 70 reported some degree of ED, and the percentage of men with more significant, complete ED tripled between age 40 and age 70.
A more recent UK study involving 12,490 men found that 41.5% men reported some degree of ED, and men with ED were noticeably more likely to also have high blood pressure, high cholesterol, diabetes, depression, or anxiety than men without it.
It's worth saying clearly: ED in your 30s or 40s is not unusual, and it doesn't automatically mean anything serious.
But it's still worth a look, both for the ED itself and for what it might be telling you about your wider health.
ED rarely has a single, tidy cause.
Most cases involve a mix of physical and psychological factors, and the balance shifts as men get older. Here's roughly how it breaks down:
For the full breakdown by decade, along with what tends to cause it at each stage, see What causes ED in your 30s, 40s, 50s, 60s.
Did you know?
A large analysis pooled from almost 93,000 men across 14 studies, published in the journal Circulation: Cardiovascular Quality and Outcomes, found that men with ED were 44% more likely to experience a cardiovascular event such as a heart attack or stroke, and 25% more likely to die from any cause, compared with men who didn't have ED.
Here's why ED could be something more than just finding it difficult to last in bed.
The blood vessels that supply the blood to the penis are narrower than the ones that supply the blood to the heart, roughly 1 to 2mm compared with 3 to 4mm.
When narrowing or stiffening starts to affect the arteries throughout the body (the medical term is atherosclerosis), the smaller penile blood vessels tend to show the strain first.
ED can turn up as an early warning sign, sometimes years before a man notices any chest symptoms at all.
This isn't a fringe idea.
It's become mainstream enough that a major panel of cardiologists and urologists, the Princeton IV Consensus, concluded in 2024 that men with ED should be treated as being at cardiac risk until proven otherwise.
NICE's own UK clinical guidance for doctors reflects the same message, and has been kept current with repeated revisions over the past two years as this evidence has built up.
That's the main reason ED deserves a proper look, not a shrug.
It isn't really a question of "is this serious enough to bother a doctor with."
For a lot of men, ED is the first and only symptom that something else needs checking, whether that's blood pressure, cholesterol, blood sugar, or testosterone.
Booking an appointment doesn't need a dramatic trigger.
Any one of these is a reasonable enough reason on its own:
None of these need to feel urgent to be worth acting on.
The point of an early appointment is to catch things while they're easy to manage, not to wait until there's a crisis.
A smaller number of situations move ED from "worth booking in for" to "get seen promptly."
None of these are meant to alarm you. They're just the specific scenarios where a same-day or urgent assessment genuinely makes a difference:
When you do visit the doctor’s office for an ED consultation, here are a few things that may take place:
A conversation. Your history, how long this has been happening, whether it's every time or sometimes, your medications, alcohol and smoking habits, and how it's affecting you.
A few checks. Blood pressure and heart rate are routine. A physical examination is more likely if there's a specific concern, such as pain, a lump, or curvature.
Sometimes, blood tests. Commonly blood sugar (or HbA1c), cholesterol, and testosterone, particularly if nothing has been checked in the last year or so. These aren't testing for ED itself. They're testing for the underlying causes ED can point towards.
A few lifestyle factors genuinely move the needle for ED, alongside whatever else you and a prescriber decide on. None of these are about blame. And they can all be implemented easily.
None of this replaces getting assessed. It's worth doing alongside it, not instead of it.
Whatever the underlying cause for ED, the first-line treatment for most men is the same class of medication, PDE5 inhibitors, which work by improving blood flow to the penis.
In the UK, four treatment options are licensed for ED: Viagra (sildenafil), Cialis (tadalafil), vardenafil, and Spedra (avanafil).
Apart from the above-mentioned treatments, UK also has a Generic Impotence Trial Pack, which includes 4 tablets of tadalafil 10mg, 4 tablets of vardenafil 10mg, and 4 tablets of sildenafil 10mg. The prices for the same starts from £49.99.
Two are available without a prescription, after a short pharmacist consultation: Viagra Connect (sildenafil) and Cialis Together (tadalafil).
Which one suits you often comes down to how long you want it to last and how you'd like to plan around it, rather than the underlying cause.
| Medicine | Active ingredient | Works in | Lasts upto | Take before sex | Price from* | Good to know |
|---|---|---|---|---|---|---|
| Viagra (branded) / Sildenafil (generic) | Sildenafil | 30 - 60 minutes | Around 4 hours | 30 - 60 minutes | Viagra from £28.99 Sildenafil from £8.99 |
Works best on an empty stomach; a heavy or fatty meal can slow it down |
| Cialis (branded) / Tadalafil (generic) | Tadalafil | Around 30 minutes | Upto 36 hours | At least 30 minutes | Cialis from £42.99 | Nicknamed "the weekend pill" for its long window |
| Cialis Daily | Tadalafil (low dose) | Builds up over a few days of daily use | Continuous, while you keep taking it | Not timed to sex, taken at the same time every day | From £72.99 | Ideal for men having sex more than twice a week |
| Vardenafil | Vardenafil | 15 - 30 minutes | Upto 5 hours | 25 - 60 minutes | Vardenafil from £29.99 | A lower-dose option sometimes suggested alongside other health conditions |
| Spedra | Avanafil | 15 - 30 minutes (often the fastest) | Up to 5 - 6 hours | Around 30 minutes | From £21.99 | A newer option; some men get on with it with fewer side effects |
PDE5 inhibitors should not be taken alongside nitrate medications (commonly prescribed for angina) or recreational nitrates ('poppers'), as the combination can cause a dangerous drop in blood pressure.
Tell your prescriber about all medications you're taking, including any for blood pressure or chest pain, before starting treatment.
Our guides on Viagra vs Sildenafil and Cialis daily vs on-demand walk through the practical differences.
This is worth knowing before you start, because it changes what "seeing a doctor" might mean the second time round.
PDE-5 inhibitors (the Viagra, Sildenafil, and Cialis family) don't work the first time for everyone, and that's not necessarily the end of the road.
UK clinical guidance sets a fairly specific bar before a medication is considered to have genuinely failed: Several attempts, at the right dose, with proper sexual stimulation, not just one disappointing try.
If you've given it a proper go and two different PDE-5 inhibitors genuinely haven't worked, that's a recognised point to go back and ask what's next, rather than assuming nothing else can help.
Options at that stage can include a different type of treatment altogether, or a referral to a specialist who deals specifically with ED.
It's a useful thing to know going in. "The tablets didn't work" is a reason to go back, not a reason to give up.
With OnlineClinic, the first part, the conversation, happens through a short online medical questionnaire rather than an in-person appointment.
Our process is straightforward. From start to finish, this is what happens when you order with us:
If anything in your answers suggests you'd benefit from blood tests, a physical examination, or a closer look at your heart health first, the prescriber will tell you directly and point you towards seeing your GP for that part.
Every price includes the prescription, the consultation, the packaging, and delivery. There are no hidden fees.
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Disclaimer
ED medications are prescription-only. Decisions about whether treatment is suitable for you are made by a GMC-registered prescriber based on your individual medical history. The information here is for general guidance and is not a substitute for professional medical advice. If you have an erection lasting more than four hours, or ED alongside chest pain or breathlessness, seek emergency medical care immediately.
Reviewed by Dr. Anup Jethwa
Reviewed by Dr. Anup Jethwa
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