Switching from Wegovy to Mounjaro: Step-by-step guide, what to expect, and more

If you are reading this article, you have probably already been on Wegovy for a while.

You know what a weekly injection feels like, you have been through the early side effects, and you have a reason for thinking about making a switch.

Maybe the weight loss has slowed.

Maybe you never quite got the result you hoped for.

Maybe you simply want to try the option that promises better results in the trials.

Whatever the reason, you are not starting from scratch, and this guide is designed for someone just like you.

It covers how the switch from Wegovy to Mounjaro actually works, what happens to your body when you switch, and what to expect when you make the switch.

However, this guide is not a recommendation to switch. That decision is made with a GMC-registered prescriber who can see your full medical history.

Before you begin: A little bit about OnlineClinic

OnlineClinic has been operating since 2011 and has treated more than 2.1 million patients.

The pharmacy is registered with the General Pharmaceutical Council (GPhC), our prescribers are registered with the General Medical Council (GMC), and the service is regulated by the Care Quality Commission (CQC).

As of July 2026, on Trustpilot, the service rating is 4.6 out of 5 based on 6,440 reviews.

Before you decide to switch from Wegovy to Mounjaro, there are a couple of recent developments to consider.

Wegovy’s maximum weekly dose is now 7.2mg

The MHRA (Medicines and Healthcare products Regulatory Agency) approved a 7.2mg maximum weekly dose for Wegovy in 2026.

That is roughly three times the old 2.4mg dose, and it helps lose upto 19% weight loss compared to the 15% weight loss that the 2.4mg dose offered.

Wegovy is now available as an oral pill

Since July 2026, Wegovy has been available as a once-daily oral pill.

It is available in four doses: 1.5mg, 4mg, 9mg, and 25mg.

In the OASIS-4 clinical trial, Wegovy pill has delivered 13.6% weight loss in 64 weeks.

If you are not comfortable with once-weekly injections, you can safely transition to the pill.

There can be several reasons for wanting to switch from Wegovy to Mounjaro. Some of the most common reasons are:

• Weight loss plateau: The scales stopped moving on the maximum Wegovy dose, and it has stayed that way for weeks.
• Not enough weight loss overall: Wegovy worked, but not to the degree that was hoped for, even at the maximum dose.
• Wanting a better alternative: Mounjaro tends to produce greater average weight loss in trials, and some people want to give that a try.
• A different tolerability picture: A minority of people find one medicine sits better with them than the other.

Both Mounjaro and Wegovy are GLP-1 receptor agonists (they both mimic the GLP-1 hormone in our bodies) and do a similar job: both medicines reduce appetite, slow how quickly your stomach empties, and are available as once-weekly injection.

But, there are some key differences that usually make people switch:

Our complete Mounjaro vs Wegovy comparison guide covers the entire side-by-side comparison in depth.

The clearest evidence on the two medicines comes from SURMOUNT-5 trial, the first trial to test them directly against each other.

SURMOUNT-5 (tirzepatide vs semaglutide)

The trial included 751 obese participants, who were either given tirzepatide (Mounjaro) or semaglutide (Wegovy) for 72 weeks.

Average weight loss at 72 weeks:

• Mounjaro (tirzepatide): 20.2%
• Wegovy (semaglutide): 13.7%

Switching from Wegovy to Mounjaro is not a complicated process. You just need to follow some simple instructions, and you’re good to go.

1. Take your last Wegovy injection as normal, then safely discard the pen.
2. Leave a gap of about one week. This means you skip Wegovy on your next dose day and let the semaglutide clear from your system.
3. Take your first Mounjaro dose at 2.5mg on your usual injection day. This is the standard starting dose for everyone.
4. Step up gradually from there, following your prescriber's plan (more on the schedule below).

One firm rule: Do not take Wegovy and Mounjaro in the same week or run them together. They are stopped and started, not overlapped.

If you and a prescriber decide the switch is right for you, you can start a free consultation, and we will confirm your changeover plan before anything is dispatched.

There is no rush, and no charge if treatment is not issued.

If you were on the maximum Wegovy dose, starting Mounjaro at 2.5mg can feel like going back to square one.

But, it is worth understanding why starting from scratch is a deliberate decision rather than just caution.

There is no official dose-equivalence between the two medicines.

Semaglutide and tirzepatide are different compounds, and there is no manufacturer chart that says "your Wegovy dose equals this Mounjaro dose.”

Because of that, the standard, evidence-backed approach is to begin Mounjaro at 2.5mg regardless of the Wegovy dose you finished on.

This lets your body get used to the second hormone (GIP) present in Mounjaro, which Wegovy never introduced, and it keeps early side effects manageable.

Some specialist prescribers may occasionally judge that a slightly higher start is appropriate based on how well you tolerated Wegovy.

That is a clinical decision for the prescriber, not something to attempt yourself. So, it’s best to talk to your prescriber before trying anything yourself.

We’ll be honest, some of the early side effects you dealt with on Wegovy can return as you build the Mounjaro dose back up.

Nausea, vomiting, reduced appetite, and the occasional bout of constipation or reflux may resurface.

But it is only because your body is getting used to the new medicine and the new dose, and your stomach is emptying more slowly.

Here is the difference for you specifically. Because your body already knows the GLP-1 effect from Wegovy, the effect from dose change and escalation on Mounjaro is often milder and shorter.

The new element that’s being introduced to your body is GIP, so you might notice a slightly different pattern of stomach symptoms than you had on Wegovy.

It usually settles within the first few weeks of each new dose.

Here are a few practical things that may help deal with the side effects:

• Eat smaller meals, since a slowed stomach makes large meals uncomfortable.
• Go easy on very high-fat foods in the first weeks of each new dose.
• Keep your fluids up, because constipation is common.
• Tell your prescriber if a side effect is not easing, since holding at a dose for an extra cycle often resolves it.

We cover the full timeline in Mounjaro side effects week by week.

Once you have started the 2.5mg Mounjaro dose, you follow a steady step-up pattern.

Mounjaro is available in six different doses: 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg.

You stay on each dose for at least four weeks before moving up, which gives your body time to adjust each time.

You do not have to climb to 15mg.

The right maintenance dose is the lowest one that gives you steady progress with side effects you can live with, and that varies from person to person.

The full dose schedule is explained in our Mounjaro dosage schedule guide.

Switching from Wegovy to Mounjaro is easy. However, there are two major caveats to keep in mind before you decide to switch.

You may need to swap your oral contraceptive pill

Mounjaro can reduce how well your body absorbs the combined oral contraceptive pill, particularly when you start, and each time the dose goes up.

Wegovy does not carry this warning.

If you take the oral contraceptive pill, you need to either switch to a non-oral method of contraception or add a barrier method (such as condoms) for four weeks after starting Mounjaro and for four weeks after every dose increase.

To understand the limitations and the alternatives in greater detail, check out our guide on Mounjaro and contraception.

You will not get Wegovy's heart health benefits

Switching from Wegovy to Mounjaro is an important decision. Rethink the switch if:

• You have established cardiovascular disease and a BMI of 27 or above, where Wegovy's heart health benefit can help significantly.
• You are tolerating Wegovy well and still losing weight steadily, in which case there may be no need to change.
• You have not yet tried the newer Wegovy 7.2mg dose or the Wegovy pill, which may be a simpler next step than switching medicine entirely.
• The contraceptive change on Mounjaro would be difficult for you to manage.

Mounjaro might not be suitable if you:

• Are pregnant, planning a pregnancy, or breastfeeding.
• Have had a serious allergic reaction to tirzepatide.

Discuss your eligibility for Mounjaro with a prescriber first if you:

• Have a history of pancreatitis or gallbladder disease
• Severe kidney or liver problems
• Diabetic retinopathy
• A history of eating disorders
• Take other diabetes medicines (particularly insulin).

To be eligible for treatment, you also need a BMI of 30 or above, or 27 or above with a weight-related health condition. If GLP-1 treatment is no longer right for you, our prescribers will let you know and explain why.

Switching between Wegovy and Mounjaro is a straightforward process at OnlineClinic. You just need to follow the steps below:

1. Fill in a short medical questionnaire (takes 5 to 10 minutes). Tell us you are currently on Wegovy, which dose, and how you have found it. The questions are thorough on purpose, so the prescriber can plan the switch safely.
2. A GMC-registered prescriber reviews your answers. If Mounjaro is suitable, they will confirm your starting dose and the timing of the changeover from Wegovy.
3. If approved, we dispense and dispatch Mounjaro. At OnlineClinic, you get next-day delivery, in temperature-controlled packaging, with the needles, sharps bin, and full patient leaflet included in the package.
4. If Mounjaro is not right for you, the prescriber tells you why. The prescriber will also talk through the alternatives. You are not charged for treatment that is not issued.

Our prices start at £139.99 for the Mounjaro 2.5mg starter pen, and every price includes the prescription, the consultation, the packaging, and next-day delivery, with no hidden fees.